An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs
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چکیده
منابع مشابه
An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs.
Retrotransposition of processed mRNAs is a common source of novel sequence acquired during the evolution of genomes. Although the vast majority of retroposed gene copies, or retrogenes, rapidly accumulate debilitating mutations that disrupt the reading frame, a small percentage become new genes that encode functional proteins. By using a multibreed association analysis in the domestic dog, we d...
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ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1173275